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desvenlafaxine will improve the stage or effect of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Keep track of. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, four hundred mg) minimize the CYP2D6 substrate dose by as many as 50%; no dosage adjustment wanted with desvenlafaxine doses seven consecutive da